1,000+ Seeds. Hypericum Perforatum, or commonly called St. John’s Wort, is a short-lived, shrubby perennial that has lovely, bright yellow flowers and is known as a medicinal herb. Sow St. John’s Wort seed indoors 6 – 8 weeks before the last expected frost. Or, for areas with a long growing season, start the seed directly outdoors in a prepared seed bed after frost danger has passed. Press the seed into the soil but do not cover it. Keep seed moist until germination. With a temperature of 60F, germination is usually within 20 days. Space the plant 18 – 24 inches apart. Grow this perennial in full sun to partial shade and in well-draining soil. St. John’s Wort is usually resistant to deer.